Additional projects aim to understand the role of Tau, Fyn, Pyk2 and STEP in Alzheimer’s disease and how these molecules interact with Abeta, how exosomes participate in the propagation of tau pathology, how tau impairs the electrophysiological properties of neurons, how tau and the kinase Fyn are transported in neurons, and how tau impairs mitochondrial functions. We are further working on the role of glia in neurodegeneration. To address brain physiology, we use click chemistry and super resolution microscopy.
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